Efficacy and safety of carbetocin applied as an intravenous bolus compared to as a short-infusion for caesarean section: study protocol for a randomised controlled trial

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Efficacy and safety of carbetocin applied as an intravenous bolus compared to as a short-infusion for caesarean section: study protocol for a randomised controlled trial

BACKGROUND The two most commonly used uterotonic drugs in caesarean section are oxytocin and carbetocin, a synthetic oxytocin analogue. Carbetocin has a longer half-life when compared to oxytocin, resulting in a reduced use of additional uterotonics. Oxytocin is known to cause fewer cardiovascular side effects when administered as a short-infusion compared to as an intravenous bolus. Based on t...

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Haemodynamic Effects of Oxytocin as Intravenous Bolus or Infusion on Women Undergoing Caesarean Section

Oxytocin is commonly used in obstetric practice as uterotonic drug for induction and augmentation of labour (1) and remains the drug of choice for facilitating uterine contractions during vaginal and operative delivery (2). Several regimens of oxytocin have been tested during cesarean delivery (CD) with variable wanted (uterotonic) and unwanted (cardiovascular) effects (3-7). When given as a ra...

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Intravenous salbutamol bolus compared with an aminophylline infusion in children with severe asthma: a randomised controlled trial.

BACKGROUND The relative efficacies of aminophylline and salbutamol in severe acute childhood asthma are currently unclear. A single bolus of salbutamol was compared with a continuous aminophylline infusion in children with severe asthma in a randomised double blind study. METHODS Children aged 1-16 years with acute severe asthma were enrolled if they showed little improvement with three nebul...

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ژورنال

عنوان ژورنال: Trials

سال: 2016

ISSN: 1745-6215

DOI: 10.1186/s13063-016-1285-5